For decades, the assassination of John F. Kennedy has fueled dark rumors of conspiracies and mishandled evidence. Now, fifty years later, NOVA asks: Could modern investigators do better? We’ll see how state-of-the art forensic tools would be applied to the investigation were it to happen today. At the same time, NOVA takes a critical look at contemporary cases, like the murders of Nicole Brown Simpson and Ronald Goldman, to reveal how charges of evidence mishandling and human error can mar even scientifically sophisticated detective work.